Irregular antibodies to red blood cells in patients of a multidisciplinary clinic

Published: 2022-02-14

    Management in health care
  • We studied the practice of transfusion therapy for patients at the Pirogov National Medical and Surgical Center, who
    were diagnosed with irregular antibodies to red blood cells (RBC) in 2020. Among hospital patients, the part of such
    immunized persons was 1,62% (200 people). Of these, the selection of donor RBC was performed in 29 (14,5%) patients.
    45 cross-matching procedures were performed, which involved 177 units of RBC. 121 units were found compatible and
    56 – incompatible. Of 29 patients with matched blood, transfusion of matched RBC was received by 14 (48,3%) people.
    They received 54 units of RBC compatible in the indirect antiglobulin test. In 2 patients, antibodies were detected during
    transfusion therapy. It is advisable to: a) create a centralized laboratory for federal medical organizations with the possibility of identifying irregular anti-RBC antibodies and individual selection of compatible donors; b) include identification of antibodies in the range of medical services; c) standardize the number of segments of the donor container tube from which RBC can be taken for cross-matching; d) establish the frequency of screening for irregular antibodies while continuing transfusion therapy; e) in a clinic of comparable scale, it is sufficient to maintain a daily supply of RBC in the amount of 2,1% – 2,8% of the annual consumption in order to provide an individual selection of blood for patients with irregular anti-RBC antibodies.

    Authors: Zhiburt E. B. [14] Kuznetsov S. I. [6] Averyanov E. G. [5] Shestakov E. A. [5]

    Tags: blood7 blood transfusion10 compatibility1 donor2 irregular antibodies1 recipient4 red blood cells2 selection1

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