2016 № 7 Methodology of creation and using of clinicoeconomic simulator for decision-makers by the example of GEP nets and pNETs
Health technology assessment (HTA) in the condition of a limited budget is an actual problem for Ministry of Health employee and persons who make a decision. Switching to single-channel financing, increasing of budgets in the hospital segment and the interaction with insurance companies force us to use the principles of technology assessment made in developed countries and to create our own tools for decision-making. We’ve designed a clinical and economic decision-making simulator for socially – significant diseases by the example of GEP NETs and pNETs.
2017 № 3 The possibility of adapting European clinical and economic models for use in the Russian routine practice to calculate the treatment of patients with diabetes mellitus type 2
The cost of the type 2 diabetes mellitus (DM2) treatment with dapagliflozin as a first-line drug, its subsequent combination with metformin and then switching to insulin therapy, were 297 321 068 rubles. This calculation based on the prospective modelling with a 25 year prognosis horizon in the cohort of 1,000 patients. In case of the first-line saxagliptin application, its following combination with metformin and then switching to insulin therapy, the costs were 297 733 828 rubles, that is at 412,760 rubles more than first-line dapagliflozin strategy. A cost-effectiveness analysis of the first-line dapagliflozin strategy in comparing with the saxagliptin treatment is not highly sensitive to changes in the price that are within 10%. In this range of price changes, the dapagliflozin strategy can be considered even more cost-effective achieving 141.38 rubles for QALY gained with an increase in the price of dapagliflozin by 10% and 244.05 rubles / QALY, while the price of saxagliptin decreases by 10%.