Foreign experience
  • 2017 № 3 The possibility of adapting European clinical and economic models for use in the Russian routine practice to calculate the treatment of patients with diabetes mellitus type 2

    The cost of the type 2 diabetes mellitus (DM2) treatment with dapagliflozin as a first-line drug, its subsequent combination with metformin and then switching to insulin therapy, were 297 321 068 rubles. This calculation based on the prospective modelling with a 25 year prognosis horizon in the cohort of 1,000 patients. In case of the first-line saxagliptin application, its following combination with metformin and then switching to insulin therapy, the costs were 297 733 828 rubles, that is at 412,760 rubles more than first-line dapagliflozin strategy. A cost-effectiveness analysis of the first-line dapagliflozin strategy in comparing with the saxagliptin treatment is not highly sensitive to changes in the price that are within 10%. In this range of price changes, the dapagliflozin strategy can be considered even more cost-effective achieving 141.38 rubles for QALY gained with an increase in the price of dapagliflozin by 10% and 244.05 rubles / QALY, while the price of saxagliptin decreases by 10%.

    Authors: Zelenova O. V. [4] Zhilina V. V. [3] Kreknina E. A. [5] Sannikov A. I. [2] Belyakova N. V. [3]

    Tags: cost-effectiveness2 diabetes mellitus type 2 (dm2)1 direct costs4 sensitivity analysis1 treatment strategy1

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  • Management in health care
  • 2016 № 8 Clinical and economic decisions for the oncology patients with choices of the treatment of the cachexia – anorexia syndrome at the patients with malignant tumors for acceptance of administrative decisions

    Present day the crucial object of cancer palliative care is improving patients quality of end-of-life and to optimize patient outcomes when they face intolerable suffering. The lack of success of unimodal treatment in cachexiaanorexia is one of the key questions that clinicians responcible and deal with a difficalty. Outcome based on our clinicoeconomic research and comparision analysis of two treatment technologies for cancer cachexia patients illustrates how and in which sequence we should make use of medical technologies and choose the most effective for the patient and save the cost of budget.

    Authors: Zelenova O. V. [4] Zhilina V. V. [3] Kreknina E. A. [5] Belyakova N. V. [3] Novikov G. A. [1] Rudoy S. V. [1]

    Tags: cachexia-anorexia syndrome1 cancer palliative care1 clinicoeconomic research and outcome1 cost-efficient1 straight cost1

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  • 2016 № 7 Methodology of creation and using of clinicoeconomic simulator for decision-makers by the example of GEP nets and pNETs

    Health technology assessment (HTA) in the condition of a limited budget is an actual problem for Ministry of Health employee and persons who make a decision. Switching to single-channel financing, increasing of budgets in the hospital segment and the interaction with insurance companies force us to use the principles of technology assessment made in developed countries and to create our own tools for decision-making. We’ve designed a clinical and economic decision-making simulator for socially – significant diseases by the example of GEP NETs and pNETs.

    Authors: Zelenova O. V. [4] Zhilina V. V. [3] Kreknina E. A. [5] Belyakova N. V. [3]

    Tags: clinical and economic simulator1 cost-effectiveness2 diagnosis1 direct costs4 drug treatment1 nets1

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