The study of the health of students of medical colleges run by the complex medical and demographic and socio-sanitary program, which included an assessment of the influence on it together regional demographic, environmental, social and economic prerequisites for registered biomedical characteristics of the organism. The study was developed and tested a complex methodology that takes into account medical and demographic and socio-hygienic characteristics as bases for the study of health, structure and disease, and to identify the health status depending on the conditions and the way of life of students of medical colleges. The results of the study, which involved more than 180 000 students from 347 medical colleges and technical schools of the Russian Federation. Representativeness of the sample was provided with a statistical error of 5%. Minimum sample size for the study of the views of college students estimated adjusted for finite population is 120 thousand observations.