2019 № 4 Knowledge-based diagnostic system for orphan diseases development
The paper discusses the problems of early diagnosis of rare hereditary origin diseases in children, presents a brief description of previously created systems aimed at providing support for physician assistance in diagnosis. The prototype of an expert diagnostic system is presented, the knowledge which combines bibliographic data on clinical cases, the coefficients of modality of signs (based on expert evaluations) and certainty factors for manifestation and severity of signs over four age periods. Such an approach to the formation of a knowledge base allows improving the quality of differential diagnosis of a rare pathology at an early age in order to start treatment on time to prevent the development of pathological manifestations caused by the accumulation of macromolecules in organs and tissues.
2018 № itm Diagnosis and treatment of liver failure: multiset model
The paper considers the use of multisets or sets with repeating elements in the modeling of diagnosis and treatment of hepatic failure, taking into account various forms of the disease, the stages of its course, variants of therapeutic tactics depending on the form of liver failure. Models “Patient with hepatic failure“ and “Treatment of hepatic failure“ allow to provide an effective selection of personalized medical tactics.
2018 № 2 Model of the patient with liver failure for use in meta-analysis, focused on selection of adequate therapy
The features of classification of liver failure in various regions of the world are analyzed. Methods for constructing mathematical models of patients and diseases have been studied. A settheoretical model of the complex clinical presentation of a patient with hepatic insufficiency, used in the process of metaanalysis, is proposed. The model takes into account the etiology and features of the disease course, as well as regional variants of classification of hepatic insufficiency in Russia, Europe, America and Asia. An example of conducting a metaanalysis according to specified criteria is given